Occupational rhinoconjunctivitis induced by unusual allergens of carrot

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Occupational asthma and dermatitis induced by eugenol in a cleaner

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Urticaria recurrente asociada a infección por Streptococcus pyogenes / Recurrent urticaria associated with group Streptococcus pyogenes infection

La mayoría de las urticarias crónicas o agudas recidivantes son idiopáticas. Presentamos un caso de urticaria aguda recidivante en una niña de tres años, en la que, tras el estudio realizado, solo se objetivó un valor elevado de anticuerpos antiestreptolisina O (ASLO). La desaparición de la urticaria tras el tratamiento con penicilina G-benzatina intramuscular, junto con la normalización de los ASLO, sugiere que la etiología de esta podría ser las infecciones recurrentes por el Streptococcus pyogenes. Destacar la importancia de incluir en el protocolo diagnóstico de la urticaria la determinación de los ASLO, lo cual permite el diagnóstico y tratamiento precoces de las infecciones por S. pyogenes (AU)

We present a case of relapsing acute urticaria in a three years old girl who after the study only showed a high value of ASLO (antistreptolysin O titer). The disappearance of urticaria after intramuscular penicillin G benzathine treatment, together with the ASLO normalization, suggested that the etiology of this could be recurrent Streptococcal infections. We conclude the importance of including ASLO determination in the diagnostic protocol of urticaria, allowing early diagnosis and treatment of Group A Streptococcus infections (AU)

Clinical profile of a Mediterranean population sensitised to date palm pollen (Phoenix dactylifera). A retrospective study

Background: Date palm pollen allergy is frequently associated with polysensitisation. Observational studies have suggested that date-palm-sensitised individuals could be included in a distinct group of polysensitised patients. The objectives of the study were to analyse the clinical characteristics of a group of patients diagnosed of date-palm pollen allergy and to compare them with pollen allergic patients without date-palm sensitisation. Methods: Forty-eight palm-pollen sensitised individuals were classified as Group A. A control group of 48 patients sensitised to pollens but without palm-pollen allergy were included as Group B. All individuals were skin prick tested with a common battery of aeroallergens. Information about age, sex, family history of atopy, respiratory symptoms, food allergy and sensitisation to other pollens were considered variables of the study. Specific IgE and the allergogram todate-palm pollen were determined in a subgroup of Group A. Results: Significant differences in the family history of atopy and number of sensitisations were observed. Both parameters were significantly higher in Group A. Group A showed high prevalence of asthma and higher level of sensitisation to foods (p < 0.05). Significant differences were obtained for sensitisation to epithelia and pollens. Pho d 2 was the most commonly recognised allergen (83.3%) in the palm-pollen allergic group. Conclusions: Date-palm pollen allergic patients constitute a homogeneous group characterised for showing bronchial asthma, sensitisation to food allergens and polysensitisation. These results suggest that the reasons for sensitisation to date-palm pollen remain to be elucidated, but could relate to the existence of as yet non-identified pan-allergens (AU)

Angioedema crónico asociado a Giardia lamblia / No disponible

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Anaphylactic shock caused by impurities in orgotein preparations

Previously reported allergic reactions to orgotein (superoxide dismutase) injections has assigned responsibility to this molecule, which is obtained from bovine liver. We report an anaphylactic shock probably caused by impurities contained in an orgotein preparation. Prick test to Peroxinorm¿ (orgotein), BSA, and cow liver extract were positive but resulted negative with chymotrypsin, milk, meat and cow epithelium extracts. Tryptase levels determined 3, 24 hours and 15 days after the shock measured 6.32, 0.81 and 0.84 U/L respectively. Detection of specific IgE to Peroxinorm¿, BSA and chymotrypsin by ELISA was negative and positive to cow liver. Specific IgE to milk and cow epithelium by Pharmacia CAP system was negative. Immunoblotting with Peroxinorm¿ revealed IgE specific bands at an apparent M.W of 67, 51, 56 and 16 kDa; immunoblotting with cow liver revealed bands at 72, 56, 50 and 36 kDa; immunoblotting with BSA and chymotypsin were negative. This case emphasises the role that 20 % of impurities of the pharmaceutical preparation may have in immediate hypersensitivity reactions (AU)

Hasta la fecha, las reacciones alérgicas por infiltraciones de orgoteína (superóxido dismutasa) se han atribuido a esta molécula, que es obtenida del hígado de vaca. Presentamos un choque anafiláctico que fue causado probablemente por impurezas presentes en un preparado de orgoteína. Las pruebas de prick con Peroxinorm (orgoteína), BSA e hígado de vaca resultaron positivas, pero fueron negativas con quimiotripsina y con extractos de leche, carne y epitelio de vaca. Los niveles de triptasa medidos a las 3, 24 horas y 15 días después de la anafilaxia fueron de 6,32, 0,81 y 0,84 U/L, respectivamente. Mediante ELISA no se detectó IgE específica para Peroxinorm , BSA ni quimiotripsina, pero el resultado fue positivo para hígado de vaca. La detección de IgE específica para leche y epitelio de vaca fue negativa mediante sistema CAP de Pharmacia. El immunoblotting con Peroxinorm mostró bandas de IgE específica en los P.M aparentes de 67, 51, 56 y 16 kDa; el immunoblotting con hígado de vaca mostró bandas en 72, 56, 50 y 36 kDa; los immunoblotting con BSA y quimiotripsina resultaron negativos. En este caso se destaca el papel que pueden tener el 20 por ciento de impurezas de este preparado en las reacciones de hipersensibilidad inmediata. (AU)